Advanced Technologies Ltd. (AT) was incorporated in 1994 in Bulgaria's capital Sofia.
The two co-founders Dr. George R. Ivanov (CV in BG/EN) and George Hristov, M.BA., (see their THEN and NOW pictures)
through his company Polymex were classmates from the most famous Bulgarian Secondary School:
The English Language School in Sofia. George Ivanov continued his scientific career in the
Institute of Solid State Physics of the Bulgarian Academy of Sciences to receive his Ph.D.
in physics. George Hristov dropped his Ph.D. in economics to concentrate on his business.
In 1999 George Ivanov bought the 49 % share of Polymex to become 100 % company owner.
George Hristov moved to another city and concentrated into his agricultural business
but is helping now and then with sound advice.
CEO and owner of Advanced Technologies Ltd. Dr. George R. Ivanov in a live prime time
show Otkrito (Open) on the Bulgarian National Television explaining the future in
front of molecular electronics and the principal advantages of AT's 4th generation of LB
film equipment (1998). Dr. Ivanov is a founding member (1990) and national coordinator of the International
Society for Molecular Electronics and BioComputing (IS MEBC). He is a member of the National
Expert Council of the National Center for Nanotechnologies.
The company originated as an Academy spin-off
company to commercialize the system for ultra thin organized organic film deposition based
on the Langmuir and Blodgett method developed from 1988 to 1990. Several redesigns were made,
first sale in Sofia University was achieved and we focused our efforts into penetrating the
East Asia markets which were most lucrative at that time. We sold 3 different systems in
Japan in 1995 and 1996, we arranged a distributor agreement with the famous Seiko Instruments,
and orders kept coming. We sold one LB film system in Republic of Korea in 1997. However we
had problems moving to mass production. The bubble burst first in Japan and the financial
problems in Korea (97 - 98) created problems in front of this production. We diversified
our products by developing the Patch-clamp amplifiers and from 96 to 99 we had sales in Japan,
Bulgaria and Italy (see patch-clamp history). Dr. Ivanov spent 1 year (2002 - 2003) as a post doc in Prof. Fred Sachs lab in the State University of New York (SUNY) in USA
working in this field - fast videocamera visualization of the patch in the patch-clamp method.
In 2001 we were ordered 2 Frequency Response
Analyzers (FRA) from the Central Laboratory for Photooptical Processes in the Bulgarian
Academy of Sciences. The instruments were delivered in 2002 and still they produce excellent
results without any repair. Recently we were ordered from the University of Chemical
Technology and Metallurgy - Sofia a system, which is based on the FRA technology and
uses the Electrochemical Impedance Spectroscopy method to monitor Fuel Cells during their
high temperature work.
With Bulgaria entering the European Union
in 2007 we have 2 focuses in our work. First is the distribution and Application
Scientist support of Atomic Force Microscopes (AFMs) in Bulgaria. Money for science infrastructure
(instruments purchase) are finally being given in Bulgaria. Since 2006 we negotiated agreement
for distribution of Anfatec Instruments (Germany) and late in 2007 imported currently
the most powerful AFM in Bulgaria with possibilities for Magnetic and Electric Force
Microcopies. Second, with free access to the EU market we would like to bring our
competitive advantage in the FRA area to the international market.
We have adopted the scientific approach and
application orientation in the design of our scientific instruments. For example the first
generation of our Langmuir-Blodgett film deposition systems was designed in several
different schemes as regard mechanical units, surface
pressure sensor, motor control, position measurement. They were thoroughly studied as
regard accuracy, response time, generated vibrations, unevenness of motion. Several
scientific publications (Refs. 1, 2, 4, 7) and some patents emerged. Our efforts were
evaluated by the scientific community and we were invited to deliver the only oral report
as regards equipment manufacture at the LB5 conference in Paris in 1991. Since 1987 we
have designed 4 generations of LB film equipment.
We continue also our research in the area of
Langmuir-Blodgett films. Our main interest is in fluorescently labeled phospholipids
because they are suitable model compounds for understanding LB films and have potential in
chemical sensor applications (Ref 3). Several new effects were found for DPPE-NBD
molecule. For the first time fluorescence self-quenching in Langmuir films was observed.
The solid phase domains are seen dark by fluorescence microscopy (Ref. 5). This allows us
to study pure single component films without use of staining dyes. LB multilayers were
studied by small-angle X-ray diffraction, polarized FTIR spectroscopy and elipsometry thus
evaluating molecular conformation in solid phase (Ref. 6). This conformation coincides
with the results from computer aided molecular conformational analysis at simulated
air-water interface. Surprisingly at pressures considerably lower than the
equilibrium spreading pressures for DPPE-NBD, bilayer structures were observed by
different scanning probe microscopy methods (AFM, FFM, SNOM, SSPM, phase imaging, Ref. 9,
12). Scanning near-field optical microscopy was also possible on a single component films
(Ref. 10). Another new effect is the influence of cobalt ions as fluorescence dequencher
on monolayers from DPPE-NBD while in bulk they are known as strong quenching agents (Ref.
8, 11). Recently we studied LB monolayers from 30 nm ferrite spheres, coated with oleic acid (Ref. 14) (see /Products/AFMs).
We also combined AFM and FLIM to the study of aggregation in LB monolayers from DPPE-NBD (Ref. 15). Some of our work on fluorescently labeled phospholipids is summarized in our book chapter (Ref. 19).
Recently we started the research on another nano material - aerogels (Ref. 18).
- G. R. Ivanov, A. T. Todorov, A. G. Petrov, "New highly precise and well defined
Langmuir-Blodgett film deposition system", in Molecular Electronics vol. 7 (1991),
ed. P.I. Lazarev, Kluwer Academic Publishers, Dordrecht, Netherlands, p. 139.
- G. R. Ivanov, A. T. Todorov, A. G. Petrov, "Langmuir trough with enhanced
performance", Makromol. Chem., Macromol. Symp., 46 (1991) 377.
- G. R. Ivanov, A. G. Petrov, "Polymorphism in Langmuir films from a fluorescently
labeled phospholipid", Mol. Cryst. Liq. Cryst., 215 (1992) 245.
- G. R. Ivanov, K.G. Kostadinov, A. G. Petrov, "Aspects of Langmuir-Blodgett trough
design: computerization, pressure measurement, unevenness of motion, generated
vibrations", Thin Solid Films, 210/211 (1992) 13.
- G. R. Ivanov, "First observation of fluorescence self-quenching in Langmuir
films", Chem. Phys. Lett., 193 (1992) 323.
- P. J. Lukes, G. R. Ivanov, M. C. Petty, J. Yarwood, M. H. Greenhall, Y. Lvov,
"Deposition and structural properties of Langmuir-Blodgett films from a fluorescently
labeled phospholipid", Langmuir, 10 (1994) 1877.
- I. I. Yovchev, B. V. Vasilev, G. R. Ivanov, "A basic Langmuir-Blodgett trough
configuration", Universite de Plovdiv, Travaux Scientifiques, 30 (1995) 25, fasc. 4
- G. R. Ivanov, J. I. Petkova, R. Brasseur, M. Fujihira, H. Takano, Y. Okabe,
"Aggregation and energy transfer in Langmuir and Langmuir-Blodgett films from a
fluorescently labeled phospholipid", in Future Directions in Thin Film Science and
Technology, eds. J. M. Marshall, N. Kirov, A. Vavrek, J. M. Maud, World Scientific,
Singapore, 1997, 381.
- G. R. Ivanov, J. I. Petkova, Y. Okabe, D. Aoki, H. Takano, H. Kawate, M. Fujihira,
"Scanning probe microscopy studies of aggregation in Langmuir-Blodgett films",
Supramolecular Science, 4 (1997) 549.
- M. Fujihira, H. Monobe, A. Koike, G. R. Ivanov, H. Muramatsu, N. Chiba, N. Yamamoto, T.
Ataka, "Application of scanning near-field optical microscopy to thin organic film
devices", Ultramicroscopy, 71 (1998) 269.
- G. R. Ivanov and M. Fujihira, "Novel phenomena in organized organic
monolayers", in Thin Film Materials and Devices - Developments in Science and
Technology, eds. J. M. Marshall, N. Kirov, A. Vavrek, J. M. Maud, World Scientific,
Singapore, 1999, 261.
- G.R. Ivanov and M. Fujihira, "Single component Langmuir-Blodgett film investigated
with 5 scanning probe microscopy methods", Colloids and Surfaces A, 198 - 200 (2002) 305.
- B. K. Tuleva, G. R. Ivanov, N. E. Christova, "Biosurfactant Production by a new Pseudomonas putida Strain
", Zeitschrift fur Naturforschung, 57c (2002) 356.
- T. Angelov, D. Radev, G. R. Ivanov, D. Antonov, I. Spirov, T. Ruskov, A. G. Petrov, "Hydrophobic
magnetic nanoparticles: synthesis and LB film preparation", J. Optoelec. Adv. Mat., 9 (2007) 424.
- G. R. Ivanov, J. I. Burov, "Nanodimentional Aggregates in Organic Monolayers
Studied with Atomic Force Microscopy (AFM) and Fluorescence Lifetime Imaging Microscopy (FLIM)",
Sixth Int. Conf. Balkan Physical Union; AIP Conf. Proc. 899 (2007) 257.
- G. As. Georgiev, A. G. Jordanova, G. R. Ivanov, Z. I. Lalchev, "Interaction of poloxamer F-98 with free standing phospholipid films ",
J. Optoelec. Adv. Mat., 11 (2009) 1241.
- G. R. Ivanov, G. As. Georgiev, Z. I. Lalchev "Monolayers from fluorescently labelled phospholipids ",
J. Optoelec. Adv. Mat., 11 (2009) 1238.
- G. R. Ivanov, R. Tomova, S. T. Djambova, M. Nadoliiski and D. Dimova-Malinovska "Functionalized aerogels - new nanomaterials for energy-efficient building. Preliminary AFM, Nanoidentation and EIS studies ",
J. Phys.: Conf. Ser., 253 (2010) 012077. Link and full text PDF.
- G. R. Ivanov, G. Georgiev and Z. Lalchev - Book chapter "Fluorescently Labeled Phospholipids - New Class of Materials for Chemical Sensors for Environmental Monitoring ",
in "Relevant Perspectives in Global Environmental Change", Julius Ibukun Agboola (Ed.), (2011) ISBN: 978-953-307-709-3, InTech Link and full text PDF.
We had developed our patch-clamp amplifiers
in collaboration with the Institute of Solid State Physics and the
Biophysics of the Bulgarian Academy of Sciences. For more info on their patch-clamp
activities visit their sites.
We are developing our Frequency
Response Amplifiers in collaboration with Prof. D.Sc. Zdr. Stoynov, from the Institute of Electrochemistry
and Energy Systems of the Bulgarian Academy of Sciences.
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